We believe in the need to evolve in a fast and professional way to guarantee innovative and state-of-the art diagnostic imaging procedures and services.

Bio Check Up Team

Research, quality, evolution and innovation

Diagnostic imaging constitutes the majority of the information contained in clinical records; the high technological evolution of the field is enormously increasing the amount and heterogeneity of this information, with a relative increase in diagnostic accuracy. It has therefore become necessary to define and develop innovative systems to safely manage the complexity of this data.

Bio Check Up activities intercept industry 4.0 and are aimed at exploiting and enhancing enabling technologies such as cloud, big-data management and cybersecurity.

Main Topics


Biomedical imaging plays a key role in health research. The BCU Imaging Biobank (BCU-IB) platform facilitates the analysis of medical imaging data and the generation of imaging biomarkers for research. The platform facilitates pipelined execution of image analysis even on large data sets. It provides the user with an XNAT, medical image repository, a flexible platform for running analysis pipelines, and a viewer for inspecting intermediate and final results.


Radiomics concerns the complete characterization of the tumor phenotype by extracting quantitative parameters from medical images for the identification of new biomarkers. Radiogenomics relates the quantitative data obtained from radiomics with the genomic data of the tumor.

Following this approach, Bio Check Up has developed efficient pipelines for the extraction of radiomic features from CT, PET or MRI images. The results obtained are used for the development of predictive models to support the diagnosis and prognosis. Furthermore, it is necessary to define appropriate platforms and algorithms to integrate the numerical information deriving from radiological imaging with those deriving from laboratory analyzes.


The rapid increase in the amount of imaging data acquired requires accurate and validated image analysis methods. The image analysis tools that can be used to extract data of interest are of enormous value and are increasingly developed.


Making images and data devoid of personal information of the patient and hospital staff is one of the requirements of the General Data Protection Regulation (GDPR) to be able to use them for scientific research purposes.

Bio Check Up has developed its own protocol for the de-identification of diagnostic images in compliance with the DICOM standard, which can be configured according to the specific type of search


The term big data refers to extremely complex data sets that are characterized by the three "Vs": volume (quantity), variety (different nature) and speed (data generation times).

Bio Check Up has as its objective the appropriate management and "care" of clinical big data through the use of tools and standards recognized and shared by the scientific community.


AI deals with the ability of IT systems to solve problems and to increase learning from the acquired experience. Through AI, Bio Check Up intends to analyse and interpret the available data to formulate hypotheses and obtain useful answers for an early diagnosis and a better treatment. This will induce a treatment defined on the specificity of the individual patient. Other applications are related to the automation of analysis of the data and the reporting processes.


Our research activities are oriented to:

  • Development of radiomic and radiogenomic methodologies
  • Optimization in the reconstruction and processing of multicenter and multimodal data
  • Optimization of quality control procedures for diagnostic procedures
  • Development of platforms for integrating and analyzing multimodal images
  • Development of an imaging biobank
  • Verification of the reproducibility of the applied analysis algorithms
  • Definition of procedures for structured reporting

An ideal operational environment

We offer the skills and an ideal operational environment for the development and technology transfer of biomedical software oriented to the management of imaging procedure, with a view to vertical integration, with a shared management of information in a cloud environment, in accordance with current regulations of sensitive data management.

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